Kyu Young Han received his BS and PhD in Chemistry from Seoul National University, Korea in 2004 and 2010. During his PhD, he worked at Max Planck Institute for Biophysical Chemistry in Germany where he achieved ultimate resolution of optical microscopy using stimulated emission depletion (STED) and ground state depletion (GSD) microscopy, and developed affordable time-gated STED. Since 2011, he has been working as a postdoc researcher at the University of Illinois, focusing on designing new optical tools for biological applications such as studying DNA-protein interactions, RNA imaging in live-cells and revealing nuclear structure in mammalian cells. His patent on STED microscopy was commercialized by Leica Microsystems.
Awards & Honors
- 2020 NIH Maximizing Investigators’ Research Award (MIRA)
We are interested in the development and applications of novel optical tools such as fluorescence nanoscopy (super-resolution imaging) and label-free single molecule imaging to study essential problems in biology and neuroscience.
Undergraduate Research Assistants
S. Basu, M. Song, L. Adams, G. Je, S. Guhathakurta, J. Jiang, N. Boparai, W. Dai, F. Cardozo-Pelaez, S.A. Tatulian, K.Y. Han, J. Elliott, J. Baum, D.W. Dicson, P.J. McLean, Y.S. Kim "Transcriptional mutagenesis of a-synuclein caused by DNA oxidation in Parkinson’s disease pathogenesis" Acta Neuropathologica (2023)
Benjamin Croop, C. Zhang, Y. Lim, R.M. Gelfand & K.Y. Han "Recent advancement of light-based single-molecule approaches for studying biomolecules (Invited Review)" Wiley Interdisciplinary Reviews-System Biology and Medicine, 11(4), e1445 (2019)
J. Tang, C.H. Weng, J.B. Oleske, and K.Y. Han "A guide to build a highly inclined swept tile microscope for extended field-of-view single-molecule imaging" JoVE - Journal of Visualized Experiments, 146, e59360 (2019)
J. Kim, K.Y. Han, N. Khanna, T. Ha, and A.S. Belmont "Nuclear speckle fusion via long-range directional motion regulates speckle morphology after transcriptional inhibition (journal cover)" Journal of Cell Science 132(8), jcs226563 (2019)
PhDBenjamin Croop, Optics Ph.D., Summer 2021
Jinhan Ren, Optics Ph.D., Summer 2021
Chenyi Zhang, Optics Ph.D., Spring 2021
Jialei Tang, Optics Ph.D., Spring 2020